Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation.

ABSTRACT: Solid organ transplantation is the treatment of choice for various end-stage diseases, but requires the continuous need for immunosuppression to prevent allograft rejection. This comes with serious side effects including increased infection rates and development of malignancies. Thus, there is a clinical need to promote transplantation tolerance to prevent organ rejection with minimal or no immunosuppressive treatment. Polyclonal regulatory T-cells (Tregs) are a potential tool to induce transplantation tolerance, but lack specificity and therefore require administration of high doses. Redirecting Tregs towards mismatched donor HLA molecules by modifying these cells with chimeric antigen receptors (CAR) would render Tregs far more effective at preventing allograft rejection. Several studies

SUBMITTER: Gille I 

PROVIDER: S-EPMC9204347 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature