Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions.

ABSTRACT:

Background

Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persists for longer than 1 h in patients with peripheral Plasmodium falciparum and no other explanation for encephalopathy. Significant research efforts on CM in the last few decades have focused on unravelling the molecular underpinnings of the disease pathogenesis and the identification of potential targets for therapeutic or pharmacologic intervention. These efforts have been greatly aided by the generation and study of mouse models of CM, which have provided great insights into key events of CM pathogenesis, revealed an interesting interplay of host versus parasite fac

SUBMITTER: Nortey LN 

PROVIDER: S-EPMC9204375 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature