Comparison of different severe obesity definitions in predicting future cardiometabolic risk in a longitudinal cohort of children.

ABSTRACT:

Objectives

Severe obesity (SO) prevalence varies between reference curve-based definitions (WHO: ≥99th percentile, Centers for Disease Control and Prevention (CDC): >1.2×95th percentile). Whether SO definitions differentially predict cardiometabolic disease risk is critical for proper clinical care and management but is unknown.

Design

Prospective cohort study SETTING: SO definitions were applied at baseline (2005-2008, M_age=9.6 years, n=548), and outcomes (fasting lipids, glucose, homoeostatic model assessment (HOMA-IR) and blood pressure) were assessed at first follow-up (F1: 2008-2011, M_age=11.6 years) and second follow-up (2015-2017, M_age=16.8 years) of the Quebec Adipose and Lifestyle Investigation in Youth cohort in Montreal, Quebec.

SUBMITTER: Kakinami L 

PROVIDER: S-EPMC9204411 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature