Non-invasive prenatal testing in mitigating concerns from invasive prenatal diagnostic testing: retrospective assessment of utility in an academic healthcare system in the US.

ABSTRACT:

Objective

Non-invasive prenatal testing (NIPT) is a front-line screening for fatal chromosomal aneuploidy. In pregnant women with a risk of having fetal congenital disorders, NIPT is anticipated to reduce the needs of invasive prenatal diagnostic test (IPD). The objective of this study was to understand the acceptance of NIPT and the utility of NIPT to mitigate concerns about IPD in the US high-risk pregnancy management.

Design and setting

This was a retrospective observational research using healthcare records obtained from an academic healthcare system in the US. The study consisted of site-level longitudinal analysis and patient-level cross-sectional analysis.

Participant

A total of 5660 new high-risk pregnancies with age ≥35 years were identified for the longitudi

SUBMITTER: Kim K 

PROVIDER: S-EPMC9204434 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature