Exposure-Response Analysis of Cardiovascular Outcome Trials With Incretin-Based Therapies.

ABSTRACT: Our study aimed to evaluate the exposure-response relationship between incretin-based medications and the risk of major adverse cardiovascular events (MACE) using cardiovascular outcome trials (CVOTs). Eleven CVOTs with incretin-based medications were included. The median follow-up time, percentage of time exposure, and hazard ratio (HR) of MACE were obtained from each CVOT. The pharmacokinetic parameters of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitor (DPP-4) were obtained from published studies. Regression analysis was performed to assess the relationship between drug exposure and MACE HR. Cutoff values were determined from the ROC curves. The linear regression results indicated that log C_max, log AUC_0-24h, and log AUC

SUBMITTER: Pan Q 

PROVIDER: S-EPMC9204533 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature