Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?

ABSTRACT: The search for efficient antimicrobial therapies that can alleviate suffering caused by infections from resistant bacteria is more urgent than ever before. Infections caused by multi-resistant pathogens represent a significant and increasing burden to healthcare and society and researcher are investigating new classes of bioactive compounds to slow down this development. Antimicrobial peptides from the innate immune system represent one promising class that offers a potential solution to the antibiotic resistance problem due to their mode of action on the microbial membranes. However, challenges associated with pharmacokinetics, bioavailability and off-target toxicity are slowing down the advancement and use of innate defensive peptides. Improving the therapeutic properties of these peptid

SUBMITTER: Svenson J 

PROVIDER: S-EPMC9204644 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature