Hypotension as a marker or mediator of perioperative organ injury: a narrative review.

ABSTRACT: Perioperative hypotension has been repeatedly associated with organ injury and worse outcome, yet many interventions to reduce morbidity by attempting to avoid or reverse hypotension have floundered. In part, this reflects uncertainty as to what threshold of hypotension is relevant in the perioperative setting. Shifting population-based definitions for hypertension, plus uncertainty regarding individualised norms before surgery, both present major challenges in constructing useful clinical guidelines that may help improve clinical outcomes. Aside from these major pragmatic challenges, a wealth of biological mechanisms that underpin the development of higher blood pressure, particularly with increasing age, suggest that hypotension (however defined) or lower blood pressure per se does not a

SUBMITTER: Ackland GL 

PROVIDER: S-EPMC9204667 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature