Phenotyping Young GluA1 Deficient Mice - A Behavioral Characterization in a Genetic Loss-of-Function Model.

ABSTRACT: Alterations of glutamatergic neurotransmission have been implicated in neurodevelopmental and neuropsychiatric disorders. Mice lacking the GluA1 AMPA receptor subunit, encoded by the Gria1 gene, display multiple phenotypical features associated with glutamatergic dysfunction. While the phenotype of adult GluA1 deficient (Gria1^-/- ) mice has been studied comprehensively, there are relevant gaps in knowledge about the course and the onset of behavioral alterations in the Gria1 knockout mouse model during post-weaning development. Based on former investigations in young wild-type mice, we exposed female and male adolescent Gria1^-/- mice to a behavioral home-cage based testing battery designed for the purpose of severity assessment. Data obtain

SUBMITTER: Reiber M 

PROVIDER: S-EPMC9204703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature