Assessment of Co-Formulants in Marketed Plant Protection Products by LC-Q-Orbitrap-MS: Application of a Hybrid Data Treatment Strategy Combining Suspect Screening and Unknown Analysis.

ABSTRACT: The aim of this study was the determination of co-formulants in 15 different chlorantraniliprole- and difenoconazole-based plant protection products (PPPs) belonging to different formulations. Samples were analyzed by ultrahigh-performance liquid chromatography coupled to Q-Orbitrap high-resolution mass accuracy spectrometry (UHPLC-Q-Orbitrap-MS), operating in full-scan MS and data-dependent acquisition (ddMS²) modes. A total of 78 co-formulants were tentatively identified by a combination of suspect screening and unknown analysis. Nine of them were later confirmed by analytical standards. Finally, the analytical method was successfully validated and co-formulants were quantified. Linear alkyl ethoxylates (LAS) were the most common type of co-formulant, followed by sodium alkylb

SUBMITTER: Maldonado-Reina AJ 

PROVIDER: S-EPMC9204808 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature