Neuroplasticity Mechanisms in Frontal Brain Gliomas: A Preliminary Study.

ABSTRACT:

Background

Pathological brain processes may induce adaptive cortical reorganization, however, the mechanisms underlying neuroplasticity that occurs in the presence of lesions in eloquent areas are not fully explained. The aim of this study was to evaluate functional compensatory cortical activations in patients with frontal brain gliomas during a phonemic fluency task and to explore correlations with cognitive performance, white matter tracts microstructural alterations, and tumor histopathological and molecular characterization.

Methods

Fifteen patients with frontal glioma were preoperatively investigated with an MRI study on a 3T scanner and a subgroup underwent an extensive neuropsychological assessment. The hemispheric laterality index (LI) was calculated through phonemi

SUBMITTER: Mitolo M 

PROVIDER: S-EPMC9204970 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature