Effect of levosimendan infusion prior to left ventricular assist device implantation on right ventricular failure

ABSTRACT:

Objective

Investigate the safety and efficacy of preoperative levosimendan in patients undergoing left ventricular assist device (LVAD) implantation.

Methods

Consecutive patients who received LVADs (HeartMate-2, 3, HVAD) in a single tertiary medical center (2012–2018). INTERMACS profile 1 patients were excluded. The primary outcome was post-LVAD right ventricular failure (RVF) and inhospital mortality rates. The secondary outcomes included other clinical, echocardiographic and hemodynamic parameters at follow-up.

Results

Final cohort consisted of 62 patients (40[65%] in the levosimendan group and 22[35%] in the no-levosimendan group). Post-operative RVF rate and inotrope or ventilation support time were similar in the levosimendan and no-levosimendan groups (7.5%

SUBMITTER: Segev A 

PROVIDER: S-EPMC9205013 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature