MiRNA-mRNA analysis of sheep adrenal glands reveals the network regulating reproduction.

ABSTRACT:

Background

The adrenal gland participates in the process of sheep reproduction. MicroRNAs (miRNAs), endogenous small noncoding RNAs, regulate gene expression at the posttranscriptional level. However, the miRNA-mRNA network profile of adrenal glands relating to reproduction in sheep is still not well-studied. As sheep with FecB^BB genotype show higher lambing number compare with the sheep with FecB⁺⁺ genotype. This research aims to compare gene expression by small RNA-seq in adrenal tissues at follicular (F) and luteal (L) phases in FecB^BB (MM) and FecB⁺⁺ (ww) sheep. After analysis of gene expression, significant differentially expressed microRNAs (DEMs) and corresponding target genes were identified.

Results

A total of 180 miRNAs w

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9205095 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature