Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma.

ABSTRACT:

Background

Intratumoral fibrosis was positively correlated with histological grade of renal clear cell carcinoma (ccRCC) and intratumoral inflammation. However, the association of intratumoral fibrosis with the immune infiltration of ccRCC was few evaluated.

Methods

We used the second harmonic generation (SHG)-based imaging technology and evaluated the intratumoral fibrosis in ccRCC, and then divided the patients into the high fibrosis group (HF) and the low fibrosis group (LF). Meanwhile, the Kaplan-Meier survival curve analysis was performed to analyze the relationship between intratumoral fibrosis and the disease-free survival rate. Antibody arrays were used for seeking difference in cytokines and immune infiltration between the HF group (N = 11) and LF group (N = 11). Th

SUBMITTER: Han S 

PROVIDER: S-EPMC9205105 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature