The study of direct and indirect effects of radiofrequency ablation on tumor microenvironment in liver tumor animal model.

ABSTRACT:

Background

Direct and indirect effects of radiofrequency ablation (RFA) on tumor microenvironment of the liver tumor have been noted, which was reported to be related to a variety of tyrosine protein kinase or cytokinetic pathway, but have not been thoroughly investigated and conclusive.

Purpose

To elucidate direct and indirect effects of RFA on tumor microenvironment in the liver tumor model, and to explore the role of the specific inhibitor in tumor growth by targeting the key pathway of RFA.

Materials and methods

One hundred and ten mice with H22 liver tumor were used in animal experiments. Eighty-four mice were randomized into three groups: control, direct RFA and indirect RFA (a block slide was inside the middle of the tumor). The growth rate of the residual tumo

SUBMITTER: Jiang AN 

PROVIDER: S-EPMC9205114 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature