IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression.

ABSTRACT:

Background

Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various inflammation-related diseases due to its early activation in inflammatory processes.

Results

In the present study, the dynamic alteration of complement C3 and its receptor C3aR during the occurrence of depression and the mechanism of astrocyte-microglia IL-1R/C3/C3aR on synaptic pruning were investigated. The proteomic analysis firstly showed that chronic stress caused an elevation of C3. GO analysis indicated that complement system-mediated synaptic pruning signaling was involved in depression. The dynamic observation indicated that C3/C3aR was activated in the

SUBMITTER: Zhang MM 

PROVIDER: S-EPMC9205119 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature