No inflammatory effects after acute inhalation of barium sulfate particles in human volunteers

ABSTRACT:

Background

Most threshold limit values are based on animal experiments. Often, the question remains whether these data reflect the situation in humans. As part of a series of investigations in our exposure lab, this study investigates whether the results on the inflammatory effects of particles that have been demonstrated in animal models can be confirmed in acute inhalation studies in humans. Such studies have not been conducted so far for barium sulfate particles (BaSO4), a substance with very low solubility and without known substance-specific toxicity. Previous inhalation studies with zinc oxide (ZnO), which has a substance-specific toxicity, have shown local and systemic inflammatory respones. The design of these human ZnO inhalation studies was adopted for BaSO4 to compare t

SUBMITTER: Monse C 

PROVIDER: S-EPMC9205122 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature