Identification of characteristic metabolic panels for different stages of prostate cancer by 1H NMR-based metabolomics analysis

ABSTRACT:

Background

Prostate cancer (PCa) is the second most prevalent cancer in males worldwide, yet detecting PCa and its metastases remains a major challenging task in clinical research setups. The present study aimed to characterize the metabolic changes underlying the PCa progression and investigate the efficacy of related metabolic panels for an accurate PCa assessment.

Methods

In the present study, 75 PCa subjects, 62 PCa patients with bone metastasis (PCaB), and 50 benign prostatic hyperplasia (BPH) patients were enrolled, and we performed a cross-sectional metabolomics analysis of serum samples collected from these subjects using a 1H nuclear magnetic resonance (NMR)-based metabolomics approach.

Results

Multivariate analysis revealed that BPH, PCa, and PCaB group

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9205125 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature