Acyl-CoA:wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina.

ABSTRACT: The daylight and color vision of diurnal vertebrates depends on cone photoreceptors. The capability of cones to operate and respond to changes in light brightness even under high illumination is attributed to their fast rate of recovery to the ground photosensitive state. This process requires the rapid replenishing of photoisomerized visual chromophore (11-cis-retinal) to regenerate cone visual pigments. Recently, several gene candidates have been proposed to contribute to the cone-specific retinoid metabolism, including acyl-CoA wax alcohol acyltransferase 2 (AWAT2, aka MFAT). Here, we evaluated the role of AWAT2 in the regeneration of visual chromophore by the phenotypic characterization of Awat2^-/- mice. The global absence of AWAT2 enzymatic activity did not affect gross ret

SUBMITTER: Widjaja-Adhi MAK 

PROVIDER: S-EPMC9205179 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature