Effect of methylprednisolone treatment on COVID-19: An inverse probability of treatment weighting analysis.

ABSTRACT:

Objectives

While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection.

Methods

Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not responding to pharmacological therapy and ventilatory support at 0.5-1mg/kg/day for 4 to 7 days. Inverse probability of treatment weighting (IPTW) was used to adjust for baseline differe

SUBMITTER: Porta L 

PROVIDER: S-EPMC9205494 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature