Fabrication of Robust Capsules by Sequential Assembly of Polyelectrolytes onto Charged Liposomes.

ABSTRACT: This work presents a simple methodology for coating small unilamellar liposomes bearing different degrees of positive charge with polyelectrolyte multilayers using the sequential layer-by-layer deposition method. The liposomes were made of mixtures of 1,2-dioleyl-sn-glycero-3-phosphocoline and dimethyl dioctadecyl ammonium bromide (DODAB) and coated by alternated layers of the sodium salt of poly(4-styrenesulfonate) (PSS) and poly(allylamine) (PAH) as polyanions and polycations, respectively. The results show that the zeta potential of the liposomes was not very sensitive to the mole fraction of DODAB in the membrane, X_D, in the range 0.3 ≤ X_D ≤ 0.8. We were able to coat the liposomes with up to four polymer bilayers. The growth of the capsule siz

SUBMITTER: Ruano M 

PROVIDER: S-EPMC9205565 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature