Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

ABSTRACT:

Objective

The relationship between human papillomavirus (HPV) and cervical lesions has been extensively elucidated, but infection with multiple genotypes is less investigated due to methodology limitations. In the current study, with a method of genotyping 21 HPVs in a routine cervical screening population, we aimed to investigate the prevalence and diversity of HPV infections in Chinese women and further evaluate the impact of multiple infections of HPV on cervical lesion progression.

Methods

Totally, 73,596 patients who underwent 21-genotype HPV testing from January 2018 to April 2019 were retrieved from the database of the Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University. HPV testing was performed by real-time PCR assay, including 13 hi

SUBMITTER: Zhong F 

PROVIDER: S-EPMC9205720 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature