Allergic Rhinitis and House Dust Mite Sensitization Determine Persistence of Asthma in Children.

ABSTRACT:

Objective

To specify clinical and immunological parameters of the mechanisms, which may lead to development of persistent asthma, or regression of the disease symptoms.

Methods

Eighty children with childhood asthma, diagnosed in the past by using the modified Asthma Predicted Index (mAPI), were divided into two groups: remission group and persistent group. There were 3 study visits (baseline, at 6 mo, and at 12 mo). Clinical remission of asthma was defined as the absence of asthma symptoms for at least 12 mo without treatment. The patients could switch from one group to another during the 12 mo of follow-up. Clinical, inflammatory, and immunoregulatory predictors of asthma remission/persistence were analyzed.

Results

The presence of mAPI criteria as well as house dust

SUBMITTER: Brzozowska A 

PROVIDER: S-EPMC9205813 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature