Pharmacological modelling of dissociation and psychosis: an evaluation of the Clinician Administered Dissociative States Scale and Psychotomimetic States Inventory during nitrous oxide ('laughing gas')-induced anomalous states.

ABSTRACT:

Rationale

A significant obstacle to an improved understanding of pathological dissociative and psychosis-like states is the lack of readily implemented pharmacological models of these experiences. Ketamine has dissociative and psychotomimetic effects but can be difficult to use outside of medical and clinical-research facilities. Alternatively, nitrous oxide (N₂O) - like ketamine, a dissociative anaesthetic and NMDAR antagonist - has numerous properties that make it an attractive alternative for modelling dissociation and psychosis. However, development and testing of such pharmacological models relies on well-characterized measurement instruments.

Objectives

To examine the factor structures of the Clinician Administered Dissociative States Scale (CADSS) and Psych

SUBMITTER: Piazza GG 

PROVIDER: S-EPMC9205822 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature