Depolarization time and extracellular glutamate levels aggravate ultraearly brain injury after subarachnoid hemorrhage.

ABSTRACT: Early brain injury after aneurysmal subarachnoid hemorrhage (SAH) worsens the neurological outcome. We hypothesize that a longer duration of depolarization and excessive release of glutamate aggravate neurological outcomes after SAH, and that brain hypothermia can accelerate repolarization and inhibit the excessive release of extracellular glutamate and subsequent neuronal damage. So, we investigated the influence of depolarization time and extracellular glutamate levels on the neurological outcome in the ultra-early phase of SAH using a rat injection model as Experiment 1 and then evaluated the efficacy of brain hypothermia targeting ultra-early brain injury as Experiment 2. Dynamic changes in membrane potentials, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, an

SUBMITTER: Murai S 

PROVIDER: S-EPMC9205962 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature