Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry.

ABSTRACT: The increasing number of positron-emission tomography (PET) tracers being developed to aid drug development and create new diagnostics has led to an increased need for radiosynthesis development and optimization. Current radiosynthesis instruments are designed to produce large-scale clinical batches and are often limited to performing a single synthesis before they must be decontaminated by waiting for radionuclide decay, followed by thorough cleaning or disposal of synthesizer components. Though with some radiosynthesizers it is possible to perform a few sequential radiosyntheses in a day, none allow for parallel radiosyntheses. Throughput of one or a few experiments per day is not well suited for rapid optimization experiments. To combat these limitations, we leverage the advantages of d

SUBMITTER: Rios A 

PROVIDER: S-EPMC9205965 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature