Cortical dopamine reduces the impact of motivational biases governing automated behaviour.

ABSTRACT: Motivations shape our behaviour: the promise of reward invigorates, while in the face of punishment, we hold back. Abnormalities of motivational processing are implicated in clinical disorders characterised by excessive habits and loss of top-down control, notably substance and behavioural addictions. Striatal and frontal dopamine have been hypothesised to play complementary roles in the respective generation and control of these motivational biases. However, while dopaminergic interventions have indeed been found to modulate motivational biases, these previous pharmacological studies used regionally non-selective pharmacological agents. Here, we tested the hypothesis that frontal dopamine controls the balance between Pavlovian, bias-driven automated responding and instrumentally learned a

SUBMITTER: Scholz V 

PROVIDER: S-EPMC9206002 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature