Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations.

ABSTRACT:

Background

COVID-19 pandemic has claimed millions of lives and devastated the health service system, livelihood, and economy in many countries worldwide. Despite the vaccination programs in many countries, the spread of the pandemic continues, and effective treatment is still urgently needed. Although some antiviral drugs have been shown to be effective, they are not widely available. Repurposing of anti-parasitic drugs with in vitro anti-SARS-CoV-2 activity is a promising approach being tested in many clinical trials. Combination of these drugs is a plausible way to enhance their effectiveness.

Methods

The in vitro anti-SARS-CoV-2 activity of combinations of niclosamide, ivermectin and chloroquine were evaluated in Vero E6 and lung epithelial cells, Calu-3.

Results

A

SUBMITTER: Jitobaom K 

PROVIDER: S-EPMC9206137 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature