Examining Tail and Headgroup Effects on Binary and Ternary Gel-Phase Lipid Bilayer Structure.

ABSTRACT: The structural properties of two- and three-component gel-phase bilayers were studied using molecular dynamics simulations. The bilayers contain distearoylphosphatidylcholine (DSPC) phospholipids mixed with alcohols and/or fatty acids of varying tail lengths, with carbon chain lengths of 12, 16, and 24 studied. Changes in both headgroup chemistry and tail length are found to affect the balance between steric repulsion and van der Waals attraction within the bilayers, manifesting in different bilayer structural properties. Lipid components are found to be located at different depths within the bilayer depending on both chain length and headgroup chemistry. The highest bilayer ordering and lowest area per tail are found in systems with medium-length tails. While longer tails can enhance van

SUBMITTER: Yang A 

PROVIDER: S-EPMC9206213 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature