Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis.

ABSTRACT:

Background

Echocardiography (2DE) is integral for screening and longitudinal evaluation of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). In the present study, we sought to establish the reliability, repeatability, and reproducibility of 2DE parameters in SSc patients with and without PAH and to define the minimal detectable difference (MDD), the smallest change detected beyond measurement error.

Methods

SSc patients without known PAH and with invasively confirmed PAH on stable therapies underwent 2DE with strain at two time points. Analysis of variance (ANOVA) and coefficients of variation (CV) were calculated to assess for repeatability, reliability, and reproducibility. Intra- and inter-observer agreement were assessed using intraclass correlation. Bla

SUBMITTER: Mukherjee M 

PROVIDER: S-EPMC9206258 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature