G4Boost: a machine learning-based tool for quadruplex identification and stability prediction.

ABSTRACT:

Background

G-quadruplexes (G4s), formed within guanine-rich nucleic acids, are secondary structures involved in important biological processes. Although every G4 motif has the potential to form a stable G4 structure, not every G4 motif would, and accurate energy-based methods are needed to assess their structural stability. Here, we present a decision tree-based prediction tool, G4Boost, to identify G4 motifs and predict their secondary structure folding probability and thermodynamic stability based on their sequences, nucleotide compositions, and estimated structural topologies.

Results

G4Boost predicted the quadruplex folding state with an accuracy greater then 93% and an F1-score of 0.96, and the folding energy with an RMSE of 4.28 and R² of 0.95 only by the me

SUBMITTER: Cagirici HB 

PROVIDER: S-EPMC9206279 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature