Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study.

ABSTRACT:

Background

Adverse ventricular structure and function is a key pathogenic mechanism of heart failure. Observational studies have shown that both insulin resistance (IR) and glycemic level are associated with adverse ventricular structure and function. However, whether IR and glycemic level are causally associated with cardiac structure and function remains unclear.

Methods

Genetic variants for IR, fasting insulin, HbA1c, and fasting glucose were selected based on published genome-wide association studies, which included 188,577, 108,557, 123,665, and 133,010 individuals of European ancestry, respectively. Outcome datasets for left ventricular (LV) parameters were obtained from UK Biobank Cardiovascular Magnetic Resonance sub-study (n = 16,923). Mendelian randomization (MR) a

SUBMITTER: Ai S 

PROVIDER: S-EPMC9206364 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature