Cobalt-electrocatalytic HAT for functionalization of unsaturated C-C bonds.

ABSTRACT: The study and application of transition metal hydrides (TMHs) has been an active area of chemical research since the early 1960s¹, for energy storage, through the reduction of protons to generate hydrogen^2,3, and for organic synthesis, for the functionalization of unsaturated C-C, C-O and C-N bonds^4,5. In the former instance, electrochemical means for driving such reactivity has been common place since the 1950s⁶ but the use of stoichiometric exogenous organic- and metal-based reductants to harness the power of TMHs in synthetic chemistry remains the norm. In particular, cobalt-based TMHs have found widespread use for the derivatization of olefins and alkynes in complex molecule construction, often by a net hydrogen atom transfer (HAT)⁷

SUBMITTER: Gnaim S 

PROVIDER: S-EPMC9206406 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature