Head-to-head evaluation of [¹⁸F]FDG and [⁶⁸ Ga]Ga-DOTA-FAPI-04 PET/CT in recurrent soft tissue sarcoma.

ABSTRACT:

Purpose

We aimed to evaluate the value of [⁶⁸ Ga]Ga-DOTA-FAPI-04 PET/CT for the diagnosis of recurrent soft tissue sarcoma (STS), compared with [¹⁸F]FDG PET/CT.

Methods

A total of 45 patients (21 females and 24 males; median age, 46 years; range, 18-71 years) with 13 subtypes of STS underwent [¹⁸F]FDG and [⁶⁸ Ga]Ga-DOTA-FAPI-04 PET/CT examination within 1 week for assessment local relapse or distant metastasis. Positive lesions on PET/CT images were verified by biopsy or 3-month follow-up. Wilcoxon matched-pairs signed-rank test was used to compare the semiquantitative values (SUV_max and TBR) of [¹⁸F]FDG and [⁶⁸ Ga]Ga-DOTA-FAPI-04 in tumor lesions, and McNemar test was applied to test for difference

SUBMITTER: Gu B 

PROVIDER: S-EPMC9206606 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature