Early-life stress exposure and large-scale covariance brain networks in extremely preterm-born infants.

ABSTRACT: The stressful extrauterine environment following premature birth likely has far-reaching and persistent adverse consequences. The effects of early "third-trimester" ex utero stress on large-scale brain networks' covariance patterns may provide a potential avenue to understand how early-life stress following premature birth increases risk or resilience. We evaluated the impact of early-life stress exposure (e.g., quantification of invasive procedures) on maturational covariance networks (MCNs) between 30 and 40 weeks of gestational age in 180 extremely preterm-born infants (<28 weeks of gestation; 43.3% female). We constructed MCNs using covariance of gray matter volumes between key nodes of three large-scale brain networks: the default mode network (DMN), executive control network (ECN), a

SUBMITTER: Lammertink F 

PROVIDER: S-EPMC9206645 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature