Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees.

ABSTRACT: We previously found an association of insulin resistance (IR) with plasma xanthine oxidoreductase (XOR) activity in a cross-sectional study. However, whether IR induces increased XOR activity has not been elucidated. This retrospective longitudinal observational study included 347 participants (173 males, 174 females) who underwent annual health examinations and were medication naïve. Homeostasis model assessment of IR (HOMA-IR) index, and physical and laboratory measurements were determined at the baseline. At baseline and 12-month follow-up examinations, plasma XOR activity was determined using our novel assay based on [¹³C₂,¹⁵N₂] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Subjects with IR, defined as HOMA-IR index 

SUBMITTER: Kurajoh M 

PROVIDER: S-EPMC9206666 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature