Drug-associated hyperammonaemia: a Bayesian analysis of the WHO Pharmacovigilance Database.

ABSTRACT:

Background

Hyperammonaemia is frequent in Intensive Care Unit patients. Some drugs have been described as associated with this condition, but there are no large-scale studies investigating this topic and most descriptions only consist of case-reports.

Methods

We performed a disproportionality analysis using VigiBase, the World Health Organization Pharmacovigilance Database, using the information component (IC). The IC compares observed and expected values to find associations between drugs and hyperammonaemia using disproportionate Bayesian reporting. An IC_0.25 (lower end of the IC 95% credibility interval) > 0 is considered statistically significant. The main demographic and clinical features, confounding factors, and severity of cases have been recorded.

Resu

SUBMITTER: Balcerac A 

PROVIDER: S-EPMC9206694 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature