Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.

ABSTRACT:

Background

Slow transit constipation (STC) is a clinical syndrome characterized by a decreased urge to defecate and delayed colonic transit. Circular RNAs (circRNAs) are a recently discovered class of regulatory RNAs that have emerged as critical biomarkers and regulators of various diseases. However, the expression profiles and mechanisms underlying circRNA regulation in human STC tissues have not been explored.

Methods

High-throughput RNA sequencing technology was used to compare the differences in circRNA expression profiles in colon samples taken from patients with STC or controls. Bioinformatics analyses were performed on the host genes of the differentially expressed circRNAs (DE-circRNAs), a competing endogenous RNA network was constructed, and the expression levels o

SUBMITTER: Xi C 

PROVIDER: S-EPMC9206760 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature