Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge.

ABSTRACT: The timing of the preovulatory surge of luteinizing hormone (LH), which occurs on the evening of proestrus in female mice, is determined by the circadian system. The identity of cells that control the phase of the LH surge is unclear: evidence supports a role of arginine vasopressin (AVP) cells of the suprachiasmatic nucleus (SCN), but it is not known whether vasopressinergic neurons are necessary or sufficient to account for circadian control of ovulation. Among other cell types, evidence also suggests important roles of circadian function of kisspeptin cells of the anteroventral periventricular nucleus (AvPV) and gonadotropin-releasing hormone (GnRH) neurons of the preoptic area (POA), whose discharge is immediately responsible for the discharge of LH from the anterior pituitary. The pre

SUBMITTER: Bittman EL 

PROVIDER: S-EPMC9206841 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature