Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure.

ABSTRACT:

Background

Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unexplored. This study sought to investigate the association of TCA cycle-related metabolites with risk of AF and HF.

Methods

We used two nested case-control studies within the PREDIMED study. During a mean follow-up for about 10 years, 512 AF and 334 HF incident cases matched by age (±5 years), sex and recruitment center to 616 controls and 433 controls, respectively, were included in this study. Baseline plasma levels of citrate, aconitate, isocitrate, succinate, malate and d/l-2-hydroxyglutarate were measured with liquid chromatography-tandem mass spectr

SUBMITTER: Bullo M 

PROVIDER: S-EPMC9206868 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature