Moyamoya syndrome and stroke among pediatric sickle cell disease patients in Sudan: A cross-sectional study.

ABSTRACT:

Background

Sickle cell disease (SCD) is autosomal recessive hemolytic anemia due to hemoglobinopathy commonly in Sub-Saharan Africa, and particularly in Sudan. The disease induces a pro-inflammatory cascade in the intimal layer that leads to hyperplasia and progressive stenosis in the major vessel of the circle of Willis. This is associated with the development of Moyamoya collaterals. The aim of this study is to highlight the frequency of Moyamoya syndrome in Sudanese pediatric patients with sickle cell disease presenting with stroke.

Materials and methods

A descriptive cross-sectional hospital-based study was conducted in the Department of Hematology at Gaafar Ibnauf Pediatric Tertiary Hospital in Khartoum state in Sudan, in the period between March 2021 and August 2021. S

SUBMITTER: Elmahdi M 

PROVIDER: S-EPMC9206931 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature