The Ratio of CD226 and TIGIT Expression in Tfh and PD-1⁺ICOS⁺Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation.

ABSTRACT: Kidney transplantation is the ideal treatment for end-stage renal disease (ESRD). Chronic antibody-mediated rejection (CAMR) is the main cause of graft failure. Tfh and B cells are key immune cells that play important roles in CAMR. In this study, the populations of different Tfh cell phenotypes and B cell subsets in CAMR were investigated in a total of 36 patients. Based on Banff-2019, 15 patients were diagnosed with CAMR (CAMR group), 11 recipients were diagnosed with recurrent or de novo IgA nephropathy (IgAN group), and 10 patients displayed stable renal function (stable group). The Tfh and B cell subsets were analyzed by flow cytometry. The percentage and absolute number of PD-1⁺ICOS⁺Tfh cells were significantly higher in CAMR (p < 0.05), as was the ratio

SUBMITTER: Fan JW 

PROVIDER: S-EPMC9206998 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature