Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model.

ABSTRACT: We expand upon prior work (Gibbons et al., ) relating childhood stressor effects, particularly harsh childhood environments, to risky behavior and ultimately physical health by adding longer-term outcomes - deoxyribonucleic acid (DNA) methylation-based measures of accelerated aging (DNA_m-aging). Further, following work on the effects of early exposure to danger (McLaughlin et al., ), we also identify an additional pathway from harsh childhood environments to DNA_m-aging that we label the danger/FKBP5 pathway, which includes early exposure to dangerous community conditions that are thought to impact glucocorticoid regulation and pro-inflammatory mechanisms. Because different DNA_m-aging indices provide different windows on accelerated aging, we contrast effect

SUBMITTER: Beach SRH 

PROVIDER: S-EPMC9207155 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature