Evaluation of C4b as an adjunct marker in symptomatic RT-PCR negative Covid-19 cases.

ABSTRACT:

Introduction

Detecting low viral load has been a challenge in this pandemic, which has led to its escalated transmission. Complement activation has been implicated in pathogenesis of Covid-19 infection. Thus, evaluation of complement activation in suspected Covid-19 infection may help to detect infection and limit false negative cases thus limiting transmission of infection. We speculate that measuring C4b, produced from an activated complement system due to the presence of Covid-19 may help in its detection, even when the viral titers are low.

Methods

Plasma C4b levels of symptomatic RT-PCR positive patients (cases, n = 40); symptomatic RT-PCR negative patients (n = 35) and asymptomatic RT-PCR negative controls (n = 40) were evaluated. Plasma C5b-9, IL-6, D-dimer and C1-Inh

SUBMITTER: Kumari B 

PROVIDER: S-EPMC9207170 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature