Causes of Kidney Graft Failure in a Cohort of Recipients With a Very Long-Time Follow-Up After Transplantation.

ABSTRACT:

Background

Biopsy-proven causes of graft loss many years after kidney transplantation are scarcely documented.

Methods

Patients transplanted between 1995 and 2005 (n = 737) in a single center were followed on a regular basis until 2021. The recipients were divided according to age at transplantation into 3 groups; 18-39 years (young), 40-55 years (middle age), and older than 55 years (elderly). For cause biopsies of renal transplants were clustered into the categories, rejection, IFTA, return original disease, and diagnosis of de novo kidney disease.

Results

Rejection was the main cause of graft failure censored for death at every time period after transplantation. The incidence of T cell-mediated rejection (TCMR) became rare 6 years after transplantatio

SUBMITTER: Betjes MGH 

PROVIDER: S-EPMC9207199 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature