Population Pharmacokinetics of Vancomycin in Pregnant Women.

ABSTRACT: Objective: Vancomycin is a glycopeptide antibacterial indicated for serious gram-positive infections. Pharmacokinetics (PK) of vancomycin have not been described in pregnant women. This study aims to characterize the PK disposition of vancomycin in pregnant women based on data acquired from a database of routine hospital care for therapeutic drug monitoring to better inform dosing decisions. Methods: In this study, plasma drug concentration data from 34 pregnant hospitalized women who were administered intravenous vancomycin was analyzed. A population pharmacokinetic (PPK) model was developed using non-linear mixed effects modeling. Model selection was based on statistical criterion, graphical analysis, and physiologic relevance. Using the final model AUC_0-24 (PK e

SUBMITTER: Goyal RK 

PROVIDER: S-EPMC9207242 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature