Systemic Lupus Erythematosus and Cardiovascular Disease: A Mendelian Randomization Study.

ABSTRACT:

Background

Previous studies have shown that patients with systemic lupus erythematosus (SLE) tend to have a higher risk of cardiovascular disease (CVD), but the potential causal relationship between genetic susceptibility to SLE and CVD risk is not clear. This study systematically investigated the potential association between genetically determined SLE and the risk of CVD.

Methods

The genetic tools were obtained from genome-wide association studies of SLE and CVD, with no overlap between their participating populations. Mendelian randomization (MR) analysis was performed using inverse variance weighting as the primary method. Simultaneously, a series of repeated analyses, sensitivity analyses, and instrumental variable strength evaluations were performed to verify the relia

SUBMITTER: Gao N 

PROVIDER: S-EPMC9207262 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature