Myeloid-Derived Suppressor Cells and Clinical Outcomes in Children With COVID-19.

ABSTRACT:

Background

Although children with COVID-19 account for fewer hospitalizations than adults, many develop severe disease requiring intensive care treatment. Critical illness due to COVID-19 has been associated with lymphopenia and functional immune suppression. Myeloid-derived suppressor cells (MDSCs) potently suppress T cells and are significantly increased in adults with severe COVID-19. The role of MDSCs in the immune response of children with COVID-19 is unknown.

Aims

We hypothesized that children with severe COVID-19 will have expansion of MDSC populations compared to those with milder disease, and that higher proportions of MDSCs will correlate with clinical outcomes.

Methods

We conducted a prospective, observational study on a convenience sample of children hospi

SUBMITTER: Bline K 

PROVIDER: S-EPMC9207271 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature