Metabolic brain pattern in dementia with Lewy bodies: Relationship to Alzheimer's disease topography.

ABSTRACT:

Purpose

Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, that shares clinical and metabolic similarities with both Alzheimer's and Parkinson's disease. In this study we aimed to identify a DLB-related pattern (DLBRP), study its relationship with other metabolic brain patterns and explore its diagnostic and prognostic value.

Methods

A cohort of 79 participants with DLB, 63 with dementia due to Alzheimer's disease (AD) and 41 normal controls (NCs) and their 2-[¹⁸F]FDG PET scans were analysed for identification and validation of DLBRP. Voxel-wise correlation and multiple linear regression were used to study the relation between DLBRP and Alzheimer's disease-related pattern (ADRP), Parkinson's disease-related pattern (PDRP) and PD-

SUBMITTER: Perovnik M 

PROVIDER: S-EPMC9207351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature