Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics.

ABSTRACT: Neuroblastoma is the most common extracranial solid tumor in children. The chromatin remodeler ATRX is frequently mutated in high-risk patients with a poor prognosis. Although many studies have reported ATRX aberrations and the associated clinical characteristics in neuroblastoma, a comprehensive overview is currently lacking. In this study, we extensively characterize the mutational spectrum of ATRX aberrations in neuroblastoma tumors reported in previous studies and present an overview of patient and tumor characteristics. We collected the data of a total of 127 neuroblastoma patients and three cell lines with ATRX aberrations originating from 20 papers. We subdivide the ATRX aberrations into nonsense, missense, and multiexon deletions (MEDs) and show that 68% of them are MEDs. Of these

SUBMITTER: van Gerven MR 

PROVIDER: S-EPMC9207354 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature