Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities.

ABSTRACT: Liquid biopsy is expected to be a promising cancer screening method because of its low invasiveness and the possibility of detecting multiple types in a single test. In the last decade, many studies on cancer detection using small RNAs in blood have been reported. To put small RNA tests into practical use as a multiple cancer type screening test, it is necessary to develop a method that can be applied to multiple facilities. We collected samples of eight cancer types and healthy controls from 20 facilities to evaluate the performance of cancer type classification. A total of 2,475 cancer samples and 496 healthy control samples were collected using a standardized protocol. After obtaining a small RNA expression profile, we constructed a classification model and evaluated its performance. Fi

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC9207371 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature